{"id":4465,"date":"2024-06-13T13:08:08","date_gmt":"2024-06-13T13:08:08","guid":{"rendered":"https:\/\/www.voxzogo.com\/en-us\/?page_id=4465"},"modified":"2025-02-20T20:00:53","modified_gmt":"2025-02-20T20:00:53","slug":"glossary","status":"publish","type":"page","link":"https:\/\/www.voxzogo.com\/en-us\/glossary\/","title":{"rendered":"Glossary"},"content":{"rendered":"<div id=\"acf-block-666b2c39bd18e\" class=\"hero hero-no-overlay\">\n                <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2024\/06\/glossary_hero_mobile-828x800.jpg); background-position: center;\"><\/div>\n            <div class=\"hero-background-image hero-background-image-tablet\" style=\"\"><\/div>\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2024\/06\/glossary_hero.jpg?v=0.156); background-position: center;\"><\/div>\n        <div class=\"overlay\"><\/div>\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"hero-content\">\n                                                    <h1>A Glossary Of Important Terms For Achondroplasia And VOXZOGO\n<\/h1>\n                                                                                    <p>Familiarizing yourself with the following terms can make understanding how VOXZOGO&#xAE; (vosoritide) works easier.<\/p>\n                                                                \t\t\t\t    <div class=\"image-caption\">\n\t\t\t\t\t    <p>Miller, 13, on VOXZOGO since 10 years old as part of a clinical trial<\/p>\n\t\t\t\t    <\/div>\n\t\t\t\t                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div id=\"acf-block-666b2c39bd54d\" class=\"banner\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"cm-glossary classic-definition\"><div class=\"glossary-container \"><input type=\"hidden\" class=\"cmtt-attribute-field\" name=\"glossary_index_style\" value=\"classic-definition\">        <div class=\"progress-indicator\" style=\"display:none\">&#13;\n                            <img decoding=\"async\" src=\"https:\/\/www.voxzogo.com\/en-us\/wp-content\/plugins\/TooltipProEcommerce\/assets\/css\/images\/ajax-loader.gif\" alt=\"AJAX progress indicator\"\/>&#13;\n                    <\/div>&#13;\n\t\t<div class=\"glossary_top_filter\">&#13;\n\t\t\t<div class=\"left\">&#13;\n\t\t\t\t\t\t\t\t\t\t<div class=\"cmtt_help glossary-search-helpitem\" data-cmtooltip=\"The search returns the partial search for the given query from both the term title and description. So it will return the results even if the given query is part of the word in the description\"><\/div>&#13;\n\t\t\t\t\t\t\t\t\t\t<div class=\"glossary-search-wrapper\">&#13;\n                        <span class=\"glossary-search-label\">Search<\/span>&#13;\n\t\t\t\t\t\t                            <input value=\"\" placeholder=\"\" class=\"glossary-search-term \" name=\"glossary-search-term\" id=\"glossary-search-term\" aria-label=\"Search\">&#13;\n                            <button type=\"submit\" id=\"glossary-search\" class=\"glossary-search button\">Search<\/button>&#13;\n&#13;\n                            <a class=\"glossary-search-clear\" title=\"Clear the input\" href=\"\">&#13;\n                                (clear)                            <\/a>&#13;\n                    <\/div>&#13;\n\t\t\t\t\t\t\t\t<\/div>&#13;\n\t\t\t\t\t<\/div>&#13;\n        &#13;\n\t\t<input type=\"hidden\" class=\"cmtt-attribute-field\" name=\"disable_listnav\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"cmtt-attribute-field\" name=\"exact_search\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"cmtt-attribute-field\" name=\"show_search\" value=\"1\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-hide-terms\" name=\"glossary-hide-terms\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-hide-categories\" name=\"glossary-hide-categories\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-hide-abbrevs\" name=\"glossary-hide-abbrevs\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-hide-synonyms\" name=\"glossary-hide-synonyms\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-perpage\" name=\"glossary-perpage\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" name=\"tooltip_language\" value=\"\">&#13;\n\t\t<input type=\"hidden\" name=\"language_dropdown\" value=\"\">&#13;\n\t\t<input type=\"hidden\" name=\"languages_for_table\" value=\"\">&#13;\n\t\t<div id=\"glossaryList-nav\" class=\"listNav medium\" role=\"tablist\"><\/div><ul class=\"glossaryList\" role=\"tablist\" id=\"glossaryList\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTermSet\"><li class=\" ln-0\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Achondroplasia<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\na type of skeletal dysplasia (a condition that affects the bones and <span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Cartilage&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;&amp;lt;!-- wp:paragraph --&amp;gt;flexible connective tissue that protects bones from rubbing against each other.&amp;lt;br\/&amp;gt;&amp;lt;!-- \/wp:paragraph --&amp;gt;&lt;\/div&gt;\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>cartilage<\/span>). While the most visible effects are in the arms, legs, and face, nearly all of the bones in the body are affected.\n<\/dfn><\/li><li class=\" ln-2\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Cartilage<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nflexible connective tissue that protects bones from rubbing against each other.\n<\/dfn><\/li><li class=\" ln-2\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">CNP<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nC-type natriuretic peptide, or <span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;CNP&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;&amp;lt;!-- wp:paragraph --&amp;gt;C-type natriuretic peptide, or CNP, is a hormone that the body naturally makes. CNP signals help to promote bone growth.&amp;lt;br\/&amp;gt;&amp;lt;!-- \/wp:paragraph --&amp;gt;&lt;\/div&gt;\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>CNP<\/span>, is a hormone that the body naturally makes. CNP signals help to promote bone growth.\n<\/dfn><\/li><li class=\" ln-4\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Efficacy (of treatment)<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\na treatment&#x2019;s ability to produce a desired benefit or effect measured in clinical trial.\n<\/dfn><\/li><li class=\" ln-4\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Endochondral bone growth<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nalso known as endochondral ossification; bone growth that replaces cartilage with bone tissue as your child grows.\n<\/dfn><\/li><li class=\" ln-5\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">FGFR3<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nfibroblast growth factor receptor 3, or <span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;FGFR3&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;&amp;lt;!-- wp:paragraph --&amp;gt;fibroblast growth factor receptor 3, or FGFR3, is a protein that sends signals that tell cells to slow bone growth.&amp;lt;br\/&amp;gt;&amp;lt;!-- \/wp:paragraph --&amp;gt;&lt;\/div&gt;\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>FGFR3<\/span>, is a protein that sends signals that tell cells to slow bone growth.\n<\/dfn><\/li><li class=\" ln-6\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Growth plates<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nareas of new bone growth seen in children and teens. <span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Growth plates&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;&amp;lt;!-- wp:paragraph --&amp;gt;areas of new bone growth seen in children and teens. Growth plates are made of cartilage but eventually become bone.&amp;lt;br\/&amp;gt;&amp;lt;!-- \/wp:paragraph --&amp;gt;&lt;\/div&gt;\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>Growth plates<\/span> are made of cartilage but eventually become bone.\n<\/dfn><\/li><li class=\" ln-8\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Injection (subcutaneous)<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\n<span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Subcutaneous&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;&amp;lt;!-- wp:paragraph --&amp;gt;under the skin in the soft, fatty layer of tissue.&amp;lt;br\/&amp;gt;&amp;lt;!-- \/wp:paragraph --&amp;gt;&lt;\/div&gt;\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>subcutaneous<\/span> injection of medicine that&rsquo;s given under the skin using a needle.\n<\/dfn><\/li><li class=\" ln-11\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Linear growth (of bones)<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\na constant rate of increase in bone growth.\n<\/dfn><\/li><li class=\" ln-18\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Side effects<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nalso known as &#x201C;adverse reactions,&#x201D; these are unwanted or undesired complications that can arise from a medication. They can be minor or more severe.\n<\/dfn><\/li><li class=\" ln-18\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Subcutaneous<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nunder the skin in the soft, fatty layer of tissue.\n<\/dfn><\/li><\/ul><\/div><div class=\"clear clearfix cmtt-clearfix\"><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-4465","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Glossary - BioMarin Voxzogo Patient EN-US<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.voxzogo.com\/en-us\/glossary\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Glossary - 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