{"id":4465,"date":"2024-06-13T13:08:08","date_gmt":"2024-06-13T13:08:08","guid":{"rendered":"https:\/\/voxzogopatient-pprd-001.azurewebsites.net\/en-us\/?page_id=4465"},"modified":"2026-06-10T10:32:06","modified_gmt":"2026-06-10T10:32:06","slug":"glossary","status":"publish","type":"page","link":"https:\/\/www.voxzogo.com\/en-us\/glossary\/","title":{"rendered":"Glossary"},"content":{"rendered":"<div id=\"acf-block-666b2c39bd18e\" class=\"hero hero-no-overlay\">\n                <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2024\/06\/glossary_hero_mobile.jpg?v=0.179); background-position: center;\"><\/div>\n            <div class=\"hero-background-image hero-background-image-tablet\" style=\"background-image: url(https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2024\/06\/glossary_hero.jpg?v=0.179); background-position: center;\"><\/div>\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2024\/06\/glossary_hero.jpg?v=0.179); background-position: center;\"><\/div>\n        <div class=\"overlay\"><\/div>\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"hero-content\">\n                                                    <h1>A Glossary Of Important Terms For Achondroplasia And VOXZOGO\n<\/h1>\n                                                                                    <p>Familiarizing yourself with the following terms can make understanding how VOXZOGO&#xAE; (vosoritide) works easier.<\/p>\n                                                                \t\t\t\t    <div class=\"image-caption\">\n\t\t\t\t\t    <p>Miller, 13, on VOXZOGO since 10 years old as part of a clinical trial<\/p>\n\t\t\t\t    <\/div>\n\t\t\t\t                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div id=\"acf-block-666b2c39bd54d\" class=\"banner\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"cm-glossary classic-definition\"><div class=\"glossary-container \"><input type=\"hidden\" class=\"cmtt-attribute-field\" name=\"glossary_index_style\" value=\"classic-definition\">        <div class=\"progress-indicator\" style=\"display:none\">&#13;\n                            <img decoding=\"async\" src=\"https:\/\/www.voxzogo.com\/en-us\/wp-content\/plugins\/TooltipProEcommerce\/assets\/css\/images\/ajax-loader.gif\" alt=\"AJAX progress indicator\"\/>&#13;\n                    <\/div>&#13;\n\t\t<div class=\"glossary_top_filter\">&#13;\n\t\t\t<div class=\"left\">&#13;\n\t\t\t\t\t\t\t\t\t\t<div class=\"cmtt_help glossary-search-helpitem\" data-cmtooltip=\"The search returns the partial search for the given query from both the term title and description. So it will return the results even if the given query is part of the word in the description\"><\/div>&#13;\n\t\t\t\t\t\t\t\t\t\t<div class=\"glossary-search-wrapper\">&#13;\n                        <span class=\"glossary-search-label\">Search<\/span>&#13;\n\t\t\t\t\t\t                            <input value=\"\" placeholder=\"\" class=\"glossary-search-term \" name=\"glossary-search-term\" id=\"glossary-search-term\" aria-label=\"Search\">&#13;\n                            <button type=\"submit\" id=\"glossary-search\" class=\"glossary-search button\">Search<\/button>&#13;\n&#13;\n                            <a class=\"glossary-search-clear\" title=\"Clear the input\" href=\"\">&#13;\n                                (clear)                            <\/a>&#13;\n                    <\/div>&#13;\n\t\t\t\t\t\t\t\t<\/div>&#13;\n\t\t\t\t\t<\/div>&#13;\n        &#13;\n\t\t<input type=\"hidden\" class=\"cmtt-attribute-field\" name=\"disable_listnav\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"cmtt-attribute-field\" name=\"exact_search\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"cmtt-attribute-field\" name=\"show_search\" value=\"1\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-hide-terms\" name=\"glossary-hide-terms\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-hide-categories\" name=\"glossary-hide-categories\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-hide-abbrevs\" name=\"glossary-hide-abbrevs\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-hide-synonyms\" name=\"glossary-hide-synonyms\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" class=\"glossary-perpage\" name=\"glossary-perpage\" value=\"0\">&#13;\n\t\t<input type=\"hidden\" name=\"tooltip_language\" value=\"\">&#13;\n\t\t<input type=\"hidden\" name=\"language_dropdown\" value=\"\">&#13;\n\t\t<input type=\"hidden\" name=\"languages_for_table\" value=\"\">&#13;\n\t\t<div id=\"glossaryList-nav\" class=\"listNav medium\" role=\"tablist\"><\/div><ul class=\"glossaryList\" role=\"tablist\" id=\"glossaryList\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTermSet\"><li class=\" ln-0\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Achondroplasia<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\na type of skeletal dysplasia (a condition that affects the bones and <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>cartilage<\/span>). While the most visible effects are in the arms, legs, and face, nearly all of the bones in the body are affected.\n<\/dfn><\/li><li class=\" ln-1\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Baseline<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nIn a <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>clinical trial<\/span>, <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>baseline<\/span> is the time when a patient is not taking any treatment, right before starting treatment.\n<\/dfn><\/li><li class=\" ln-1\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Body proportionality<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nDescribes how similar in length different parts of the body are in comparison to each other (like arm span vs height), which can impact daily functioning.\n<\/dfn><\/li><li class=\" ln-2\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Cartilage<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nflexible connective tissue that protects bones from rubbing against each other.\n<\/dfn><\/li><li class=\" ln-2\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Clinical trial<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nA type of research study that tests medical treatments to determine if the therapy is safe and effective for specific medical conditions. The result of clinical trials are used by the FDA to determine if the treatment is FDA approved for use.\n<\/dfn><\/li><li class=\" ln-2\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">CNP<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nC-type natriuretic peptide, or <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>CNP<\/span>, is a hormone that the body naturally makes. CNP signals help to promote bone growth.\n<\/dfn><\/li><li class=\" ln-4\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Efficacy (of treatment)<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\na treatment&#x2019;s ability to produce a desired benefit or effect measured in clinical trial.\n<\/dfn><\/li><li class=\" ln-4\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Endochondral bone growth<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nalso known as endochondral ossification; bone growth that replaces cartilage with bone tissue as your child grows.\n<\/dfn><\/li><li class=\" ln-5\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">FGFR3<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nfibroblast growth factor receptor 3, or <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>FGFR3<\/span>, is a protein that sends signals that tell cells to slow bone growth.\n<\/dfn><\/li><li class=\" ln-6\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Growth plates<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nareas of new bone growth seen in children and teens. <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>Growth plates<\/span> are made of cartilage but eventually become bone.\n<\/dfn><\/li><li class=\" ln-11\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Linear growth (of bones)<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\na constant rate of increase in bone growth.\n<\/dfn><\/li><li class=\" ln-14\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Open-label extension study<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nThe long-term follow-up study of the same clinical trial that was conducted for FDA approval of the medication. The study aims to follow the same patients to evaluate the continued safety and efficacy of the treatment for a longer time beyond the primary study period.\n<\/dfn><\/li><li class=\" ln-15\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Placebo group<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nIn a clinical trial, the group of patients that get an inactive treatment that looks just like an active treatment (so they think the treatment is real). This group serves as a control comparison for the group of patients who are taking the active treatment, which&#xA0; helps doctors figure out if the real medicine actually works better than just believing you are getting treatment.\n<\/dfn><\/li><li class=\" ln-18\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Side effects<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nalso known as &#x201C;adverse reactions,&#x201D; these are unwanted or undesired complications that can arise from a medication. They can be minor or more severe.\n<\/dfn><\/li><li class=\" ln-18\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">Subcutaneous injection (of medicine)<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nMedicine that's given with a needle under the skin (in the soft, fatty layer above the muscle tissue), unlike routine vaccinations (flu shot) that go deeper into the muscle tissue.\n<\/dfn><\/li><li class=\" ln-21\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\" role=\"tab\"><span role=\"term\" class=\"glossaryLink glossary-link-title \" style=\"\" itemprop=\"url\"><span itemprop=\"name\">VOXZOGO<\/span><\/span><dfn class=\"glossary_itemdesc\" role=\"definition\" itemprop=\"description\">\nAlso known as vosorotide. <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>VOXZOGO<\/span> is the longest studied medication for children with <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>achondroplasia<\/span> that is FDA approved from birth until growth close to increase linear growth.\n<\/dfn><\/li><\/ul><\/div><div class=\"clear clearfix cmtt-clearfix\"><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-4465","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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