{"id":5482,"date":"2025-10-14T10:19:47","date_gmt":"2025-10-14T10:19:47","guid":{"rendered":"https:\/\/www.voxzogo.com\/en-us\/?page_id=5482"},"modified":"2025-12-18T22:11:34","modified_gmt":"2025-12-18T22:11:34","slug":"understanding-the-data","status":"publish","type":"page","link":"https:\/\/www.voxzogo.com\/en-us\/understanding-the-data\/","title":{"rendered":"Understanding the data"},"content":{"rendered":"
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Understanding Body Proportionality\n<\/h1>\n

Achondroplasia affects body proportionality, which can impact daily functioning. Continue learning below and sign up for a VOXZOGO event led by doctors and caregivers.<\/p>\n

Join An Event<\/a><\/p>\n \t\t\t\t

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Elijah, 20 months old, on VOXZOGO since 12 months old as part of a clinical trial<\/p>\n\t\t\t\t <\/div>\n\t\t\t\t <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n\n

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The impact of VOXZOGO continues to be studied<\/h2>\n

VOXZOGO is approved under accelerated approval based on an improvement in growth rate after 1 year of treatment. Compared to untreated patients in the study, body proportionality did not worsen at 1 year.<\/p>\n

Because achondroplasia<\/span> is a condition that affects multiple aspects of physical development, additional studies on the impact of VOXZOGO over a longer period of time are ongoing, including its effects on final adult height and body proportionality<\/strong>.<\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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What is body proportionality?<\/h2><\/h2>\n \n \n

The term “body proportionality” describes how similar in length different parts of the body are in comparison with each other.<\/p>\n

Doctors measure body proportionality because it can impact daily functioning, such as reaching for items and self-grooming, and can result in the dependence on devices or caregiver assistance.<\/p>\n

Toggle between the 2 examples to see how it is commonly measured.<\/em><\/p>\n <\/div>\n

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What is body proportionality?<\/h2><\/h2>\n \n \n

The term “body proportionality” describes how similar in length different parts of the body are in comparison with each other.<\/p>\n

Doctors measure body proportionality because it can impact daily functioning, such as reaching for items and self-grooming, and can result in the dependence on devices or caregiver assistance.<\/p>\n

Toggle between the 2 examples to see how it is commonly measured.<\/em><\/p>\n <\/div>\n

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\n Upper vs lower body length <\/div>\n
\n Arm span length vs height <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Measuring upper vs lower body length ratio<\/h2><\/h2>\n \n \n

This common measurement is calculated by dividing the length of the upper body with the length of the lower body.<\/p>\n

Toggle the buttons to see the difference between a proportionate and disproportionate measurement.<\/em><\/p>\n <\/div>\n

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Measuring upper vs lower body length ratio<\/h2><\/h2>\n \n \n

This common measurement is calculated by dividing the length of the upper body with the length of the lower body.<\/p>\n

Toggle the buttons to see the difference between a proportionate and disproportionate measurement.<\/em><\/p>\n <\/div>\n

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\n Proportionate ratio <\/div>\n
\n Disproportionate ratio <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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A ratio of 1.0 means the upper body is proportionate to the lower body.<\/h4>\n

A ratio higher than 1.0 means the upper body and lower body are considered disproportionate.<\/h4>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Body proportionality in people with achondroplasia<\/h2><\/h2>\n \n \n

One characteristic feature of achondroplasia is disproportionate growth. This often results in a longer upper body length compared to the lower body.<\/i><\/p>\n

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Notice how the upper body length remains about 1.7x longer than the lower body length in an adult with achondroplasia<\/span>.<\/strong><\/p>\n <\/div>\n

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Body proportionality in people with achondroplasia<\/h2><\/h2>\n \n \n <\/div>\n <\/div>\n \n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Achondroplasia affects how body proportions change over time<\/h2><\/h2>\n \n \n

At birth, all individuals have a greater upper body length compared to their lower body.<\/p>\n

As average-stature individuals grow over time, their upper and lower body lengths become proportionate by around 10 years old.<\/p>\n

For people with achondroplasia<\/span>, the upper body remains longer than the lower body, even into adulthood.<\/strong><\/i><\/p>\n

Toggle the buttons to gain a better understanding.<\/i><\/p>\n <\/div>\n

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Achondroplasia affects how body proportions change over time<\/h2><\/h2>\n \n \n

At birth, all individuals have a greater upper body length compared to their lower body.<\/p>\n

As average-stature individuals grow over time, their upper and lower body lengths become proportionate by around 10 years old.<\/p>\n

For people with achondroplasia<\/span>, the upper body remains longer than the lower body, even into adulthood.<\/strong><\/i><\/p>\n

Toggle the buttons to gain a better understanding.<\/i><\/p>\n <\/div>\n

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\n Average stature <\/div>\n
\n In achondroplasia <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Upper vs lower body length ratio remains disproportionate
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Body proportionality was measured in children aged 5 to 15 years treated with VOXZOGO or placebo over 1 year<\/h2>\n

In a clinical trial, the impact of VOXZOGO on body proportionality was measured after 1 year. Results were measured by the change of upper vs lower body length ratio from baseline<\/strong> (before treatment was started).<\/p>\n

For both groups, the ratio decreased from before treatment by a very small amount. After 1 year, the placebo group decreased from 2.01 to 1.98<\/strong> and the VOXZOGO group decreased from 1.98 to 1.95<\/strong>. The ratio difference from placebo after 1 year of treatment was -0.01 with VOXZOGO.<\/p>\n

A lower ratio number means that body disproportionality decreased from before treatment was started. These results show that after 1 year, body proportionality did not worsen for both groups.<\/p>\n <\/div>\n\n

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Body proportionality was continually measured in a subset of VOXZOGO-treated children over 4 years<\/h2>\n

In the long-term follow-up study of the same clinical trial (known as an open-label extension), body proportionality was continually measured in VOXZOGO-treated children over 4 years. The average upper vs lower body length ratio<\/strong> for all children at each study visit is plotted in this graph, starting from baseline and for every yearly study visit until year 4.<\/p>\n

Limitations<\/strong><\/p>\n