{"id":59,"date":"2022-11-28T20:52:54","date_gmt":"2022-11-28T20:52:54","guid":{"rendered":"https:\/\/voxzogohcp-dev-001.azurewebsites.net\/en-us\/voxzogo\/?page_id=59"},"modified":"2024-11-14T01:16:15","modified_gmt":"2024-11-14T01:16:15","slug":"understanding-achondroplasia","status":"publish","type":"page","link":"https:\/\/www.voxzogo.com\/en-us\/understanding-achondroplasia\/","title":{"rendered":"Understanding achondroplasia"},"content":{"rendered":"
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Why Starting Treatment
\nEarly Matters\n<\/h1>\n \t\t\t\t
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Annika, 14, on VOXZOGO since 9 years old as part of a clinical trial<\/p>\n\t\t\t\t <\/div>\n\t\t\t\t <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n\n

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Bones grow only for a limited time.<\/h2>\n

Most bones start to grow before birth and continue for as long as bones growth plates<\/span> stay open. As long as children’s growth plates remain open, there is an opportunity for growth.<\/p>\n <\/div>\n\n

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VOXZOGO works alongside the body’s natural CNP to increase signaling and improve the balance.<\/h2>\n

A balance between fibroblast growth factor receptor 3 (FGFR3<\/span>) and C-type natriuretic peptide (CNP<\/span>) signaling pathways occurs within the cells in the growth plate. In achondroplasia<\/span>, FGFR3 sends more signals to slow bone growth than it should. VOXZOGO increases CNP signaling, alongside the body’s natural CNP, to improve bone growth.<\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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By increasing CNP signaling, VOXZOGO®<\/sup> (vosoritide) increases the rate of bone growth.<\/h2>\n <\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n
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\n\t\t\t Watch how VOXZOGO works <\/a>\n\t\t <\/div>\n \n \n \n\t\t <\/div>\n \n
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Find out how VOXZOGO works alongside the body’s natural CNP to increase growth signals.<\/h3>\n

Watch how VOXZOGO works<\/a><\/p>\n <\/div>\n \t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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Have additional questions?<\/h2>\n <\/div>\n
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Have a local BioMarin Representative connect with you.<\/h3>\n \n

Connect With a Rep<\/a><\/p>\n <\/div>\n <\/div> \n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-59","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nVOXZOGO\u00ae (vosoritide) | How VOXZOGO\u00ae Works<\/title>\n<meta name=\"description\" content=\"Learn how VOXZOGO\u00ae (vosoritide) works.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.voxzogo.com\/en-us\/understanding-achondroplasia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"VOXZOGO\u00ae (vosoritide) | How VOXZOGO\u00ae 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