{"id":61,"date":"2022-11-28T20:54:11","date_gmt":"2022-11-28T20:54:11","guid":{"rendered":"https:\/\/voxzogohcp-dev-001.azurewebsites.net\/en-us\/voxzogo\/?page_id=61"},"modified":"2025-12-17T17:08:27","modified_gmt":"2025-12-17T17:08:27","slug":"voxzogo-safety","status":"publish","type":"page","link":"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/","title":{"rendered":"VOXZOGO Safety"},"content":{"rendered":"<div id=\"acf-block-6668b1037650d\" class=\"block wrapped-content bg-band bg-band-secondary block-zero-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-6668b10376680\" class=\"block-wysiwyg\">\n            <h1 style=\"margin-bottom:0rem\">The Safety Of VOXZOGO Was Studied In 2 Robust Clinical Studies<\/h1>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f60235e21ec\" class=\"block wrapped-content block-zero-top\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f60235e2203\" class=\"block-wysiwyg\">\n            <h2>It&#x2019;s important to know:<\/h2>\n<ul>\n<li>VOXZOGO may cause serious <span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Side effects&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;&amp;lt;!-- wp:paragraph --&amp;gt;also known as &amp;quot;adverse reactions,&rdquo; these are unwanted or undesired complications that can arise from a medication. They can be minor or more severe.&amp;lt;br\/&amp;gt;&amp;lt;!-- \/wp:paragraph --&amp;gt;&lt;\/div&gt;\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>side effects<\/span>, including a temporary decrease in blood pressure in some children<\/li>\n<li>You can reduce the risk of decreased blood pressure and associated symptoms (dizziness, feeling tired, or nausea) by following these steps in the hour prior to receiving VOXZOGO:\n<ul>\n<li><strong>Be well fed <\/strong><\/li>\n<li><strong>Be well hydrated<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f60235e21ec\" class=\"block wrapped-content block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f60235e2203\" class=\"block-wysiwyg\">\n            <h2>These side effects were observed in children aged 5 to 15.<\/h2>\n<p>This table shows the number (n) of patients who experienced the most common side effects seen in more than 10% of VOXZOGO&#xAE; (vosoritide) patients over 1 year in a clinical trial*<\/p>\n    <\/div>\n\n<figure id=\"acf-block-66681a47c71d4\">\n    <div class=\"image image-rounded image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2024\/06\/BVOX_PatWebSite_SideEffects_Graphic_4.png?v=0.153\" alt=\"Table listing the most common side effects observed in children aged 5 to 15.\"\/>            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-66681a47c7202\" class=\"block-wysiwyg\">\n            <p style=\"color: #707070;font-size: .8rem\">*Includes adverse reactions occurring in over 10% of VOXZOGO patients and more frequently in the VOXZOGO arm with a risk difference of &ge;5% (ie, difference of &gt;2 subjects) between treatment arms.<br>\n<sup>&#x2020;<\/sup>Injection site reactions occurring more frequently in VOXZOGO-treated subjects than placebo.<br>\n<sup>&#x2021;<\/sup>Includes the preferred terms: gastroenteritis and gastroenteritis, viral.<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f60235e21ec\" class=\"block wrapped-content block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f60235e2203\" class=\"block-wysiwyg\">\n            <h2>The overall safety profile of VOXZOGO in children under the age of 5 was similar to that seen in children aged 5 and up.<\/h2>\n<p>The most common side effects seen in over 10% of VOXZOGO<sup>&#xAE;<\/sup> (vosoritide) patients under 5 years of age were injection site reactions (86%) and rash (28%).<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-666759e2d5f38\" class=\"block boxed-content block-tight-top block-tight-bottom\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t\t\t\t\t\n<div id=\"acf-block-66680009bfb50\" class=\"block-wysiwyg\">\n            <h2>97% of children aged 5 to 15 (58\/60) continued to take VOXZOGO after 1 year<sup>&#xA7;<\/sup><\/h2>\n    <\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f60235e21ec\" class=\"block wrapped-content block-zero-top\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-66681a47c730f\" class=\"block-wysiwyg\">\n            <p style=\"color: #707070;font-size: .8rem\"><sup>&#xA7;<\/sup>1 child discontinued due to injection pain, and 1 child discontinued due to fear of needles.<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-66682eba14268\" class=\"block wrapped-content bg-band bg-band-secondary block-tight-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-66682eba1428e\" class=\"block-wysiwyg\">\n            <h4>Learn more about how to give VOXZOGO to your child.<\/h4>\n<p><a class=\"button button-arrow\" href=\"https:\/\/www.voxzogo.com\/en-us\/giving-voxzogo-to-your-child\/\" target=\"_self\">Get more details<\/a><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-6673ed165591e\" class=\"block wide-call-to-action block-tight-top block-zero-top block-tight-bottom block-zero-bottom\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cta-content\">\n                                    <div class=\"title-block\">\n                        <h2>Have additional questions?<\/h2>\n                    <\/div>\n                                <div class=\"content-block\">\n                                            <h3>Have a local BioMarin Representative connect with you.<\/h3>\n                                                                \n                        <p><a class=\"button button-ghost button-arrow\" href=\"https:\/\/www.voxzogo.com\/en-us\/connect-with-a-rep\/\" target=\"_self\">Connect With a Rep<\/a><\/p>\n                                    <\/div>\n            <\/div>            \n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-61","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>VOXZOGO\u00ae (vosoritide) | Clinical Trial<\/title>\n<meta name=\"description\" content=\"Explore how VOXZOGO\u00ae (vosoritide) was studied in clinical trials of pediatric patients 5 years and older.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"VOXZOGO\u00ae (vosoritide) | Clinical Trial\" \/>\n<meta property=\"og:description\" content=\"Explore how VOXZOGO\u00ae (vosoritide) was studied in clinical trials of pediatric patients 5 years and older.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/\" \/>\n<meta property=\"og:site_name\" content=\"BioMarin Voxzogo Patient EN-US\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-17T17:08:27+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/\",\"url\":\"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/\",\"name\":\"VOXZOGO\u00ae (vosoritide) | Clinical Trial\",\"isPartOf\":{\"@id\":\"https:\/\/www.voxzogo.com\/en-us\/#website\"},\"datePublished\":\"2022-11-28T20:54:11+00:00\",\"dateModified\":\"2025-12-17T17:08:27+00:00\",\"description\":\"Explore how VOXZOGO\u00ae (vosoritide) was studied in clinical trials of pediatric patients 5 years and older.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.voxzogo.com\/en-us\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"VOXZOGO Safety\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.voxzogo.com\/en-us\/#website\",\"url\":\"https:\/\/www.voxzogo.com\/en-us\/\",\"name\":\"BioMarin Voxzogo Patient EN-US\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.voxzogo.com\/en-us\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"VOXZOGO\u00ae (vosoritide) | Clinical Trial","description":"Explore how VOXZOGO\u00ae (vosoritide) was studied in clinical trials of pediatric patients 5 years and older.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/","og_locale":"en_US","og_type":"article","og_title":"VOXZOGO\u00ae (vosoritide) | Clinical Trial","og_description":"Explore how VOXZOGO\u00ae (vosoritide) was studied in clinical trials of pediatric patients 5 years and older.","og_url":"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/","og_site_name":"BioMarin Voxzogo Patient EN-US","article_modified_time":"2025-12-17T17:08:27+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/","url":"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/","name":"VOXZOGO\u00ae (vosoritide) | Clinical Trial","isPartOf":{"@id":"https:\/\/www.voxzogo.com\/en-us\/#website"},"datePublished":"2022-11-28T20:54:11+00:00","dateModified":"2025-12-17T17:08:27+00:00","description":"Explore how VOXZOGO\u00ae (vosoritide) was studied in clinical trials of pediatric patients 5 years and older.","breadcrumb":{"@id":"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.voxzogo.com\/en-us\/voxzogo-safety\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.voxzogo.com\/en-us\/"},{"@type":"ListItem","position":2,"name":"VOXZOGO Safety"}]},{"@type":"WebSite","@id":"https:\/\/www.voxzogo.com\/en-us\/#website","url":"https:\/\/www.voxzogo.com\/en-us\/","name":"BioMarin Voxzogo Patient EN-US","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.voxzogo.com\/en-us\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.voxzogo.com\/en-us\/wp-json\/wp\/v2\/pages\/61","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.voxzogo.com\/en-us\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.voxzogo.com\/en-us\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.voxzogo.com\/en-us\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.voxzogo.com\/en-us\/wp-json\/wp\/v2\/comments?post=61"}],"version-history":[{"count":142,"href":"https:\/\/www.voxzogo.com\/en-us\/wp-json\/wp\/v2\/pages\/61\/revisions"}],"predecessor-version":[{"id":6243,"href":"https:\/\/www.voxzogo.com\/en-us\/wp-json\/wp\/v2\/pages\/61\/revisions\/6243"}],"wp:attachment":[{"href":"https:\/\/www.voxzogo.com\/en-us\/wp-json\/wp\/v2\/media?parent=61"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}