{"id":6379,"date":"2026-04-29T11:12:25","date_gmt":"2026-04-29T11:12:25","guid":{"rendered":"https:\/\/voxzogopatient-pprd-001.azurewebsites.net\/en-us\/?page_id=6379"},"modified":"2026-06-11T12:50:47","modified_gmt":"2026-06-11T12:50:47","slug":"inhibited-bone-growth","status":"publish","type":"page","link":"https:\/\/www.voxzogo.com\/en-us\/inhibited-bone-growth\/","title":{"rendered":"Inhibited Bone Growth"},"content":{"rendered":"
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The impact of inhibited bone growth<\/span><\/h1>\n

In achondroplasia, endochondral bone growth is inhibited throughout the body<\/h2>\n

Bones grow for a limited time. In achondroplasia<\/span>, the growth of bones that develop from cartilage<\/span> (called endochondral bones) is inhibited. This can impact physical development, including reduced and disproportionate growth.<\/strong><\/p>\n

See how physical development is tracked for children with achondroplasia.<\/p>\n

Download Growth Charts<\/a><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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Endochondral bone growth is inhibited in achondroplasia—that’s over 90% of the body’s bones.<\/h2>\n <\/div>\n <\/div>\n \n
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The most rapid growth occurs in the first 2 years of life<\/h2>\n


\nBy 2 years old, children with achondroplasia<\/span> reach more than half of their adult height*<\/strong><\/p>\n <\/div>\n\n

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*Based on stature-for-age data (birth to 18 years old) from CLARITY, an achondroplasia natural history study comprising measurements from 549 males and 502 females with achondroplasia.<\/small><\/p>\n<\/figcaption>\n <\/figure>\n <\/div>\n <\/div>\n<\/div>\n\n

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Bone growth is inhibited by imbalanced cell signals<\/h2>\n

Endochondral bone growth<\/span> occurs in areas of the bones called growth plates<\/span> and requires a balance of two cell signals—FGFR3 (which slows growth) and CNP<\/span> (which promotes growth). In achondroplasia<\/span>, the FGFR3<\/span> signals are overactive, causing an imbalance that inhibits bone growth.<\/strong><\/p>\n <\/div>\n\n

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This graphic is an illustration of the cell signaling imbalance in achondroplasia and is not to scale.
\n<\/small>CNP<\/span><\/strong>, C-type natriuretic peptide; FGFR3<\/span><\/strong>, fibroblast growth factor receptor 3.<\/small><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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See how VOXZOGO works<\/h3>\n \n

Treatment to help promote bone growth from birth.<\/p>\n \n \n \"\"\/ Learn More <\/a>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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\n \"Achondroplasia <\/div>\n\n
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Tracking your child’s growth<\/h3>\n

Growth charts specific to children with achondroplasia are important when tracking physical development.<\/p>\n \n Download<\/a>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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Looking for more information about VOXZOGO?<\/h2>\n <\/div>\n
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Your local BioMarin representative can help you find answers.<\/p>\n \n

Connect Now<\/a><\/p>\n <\/div>\n <\/div> \n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-6379","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nInhibited Bone Growth: Causes, Cell Signaling Imbalance, and Health-related Impacts in Achondroplasia| VOXZOGO\u00ae<\/title>\n<meta name=\"description\" content=\"Learn about inhibited bone growth, including causes and how it impacts physical development early in life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.voxzogo.com\/en-us\/inhibited-bone-growth\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" 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