{"id":6383,"date":"2026-04-29T11:19:10","date_gmt":"2026-04-29T11:19:10","guid":{"rendered":"https:\/\/voxzogopatient-pprd-001.azurewebsites.net\/en-us\/?page_id=6383"},"modified":"2026-06-17T10:01:18","modified_gmt":"2026-06-17T10:01:18","slug":"understanding-safety","status":"publish","type":"page","link":"https:\/\/www.voxzogo.com\/en-us\/understanding-safety\/","title":{"rendered":"Understanding Safety"},"content":{"rendered":"<div id=\"acf-block-6668b1037650d\" class=\"block wrapped-content bg-band bg-band-white block-zero-top block-tight-bottom block-remove-bottom-padding\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-6668b10376680\" class=\"block-wysiwyg\">\n            <h1>VOXZOGO safety data<\/h1>\n<h2>FDA approved to start as early as birth and studied over time<\/h2>\n<h3>Children 5 to 15 years old<\/h3>\n<p>Below are the most common <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>side effects<\/span> seen in over 10% of children (aged 5 to 15 years) on <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>VOXZOGO<\/span> over 1 year in a <span class=\"\"  data-mobile-support=\"0\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>clinical trial<\/span>.*<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69fb5d002f90e\" class=\"block wrapped-content block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<figure id=\"acf-block-69fb5d002fb6b\">\n    <div class=\"image image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2026\/04\/Safety_side-effect-desktop.png?v=0.179\" alt=\"Table comparing VOXZOGO vs placebo side effects in clinical trials, including injection site reactions and vomiting\"\/>            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-69fb5d002fb99\" class=\"block-wysiwyg\">\n            <h3 style=\"text-align: center\">In ongoing studies of VOXZOGO, the side effects observed for up to 6 years of treatment are similar to those seen in the first year.<\/h3>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69fb5d002fe01\" class=\"block call-to-action vox-cta lightpurple\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"box\">\n                <div class=\"vox-cta-content\">\n                                            <div class=\"top-image\">\n                            <img decoding=\"async\" class=\"\" src=\"https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2026\/04\/important.svg\" alt=\"\"\/>                        <\/div>\n                                        \n                                            <h3>It&#x2019;s important to know:<\/h3>\n                                        \n                                            <ul>\n<li>VOXZOGO may cause serious side effects, including a temporary decrease in blood pressure in some patients<\/li>\n<li>You can reduce the risk of decreased blood pressure and associated symptoms (dizziness, feeling tired, or nausea) by following these steps in the hour before receiving VOXZOGO:\n<ul>\n<li>Be well fed<\/li>\n<li>Be well hydrated<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n                                        \n                                    <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69fb5d002fe63\" class=\"block wrapped-content block-zero-top\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-69fb5d002fe8a\" class=\"block-wysiwyg\">\n            <p><small>*Includes adverse reactions occurring in over 10% of VOXZOGO patients and more frequently in the VOXZOGO arm with a risk difference of &ge;5% (ie, difference of &gt;2 subjects) between treatment arms.<\/small><br>\n<small><sup>&#x2020;<\/sup>Injection site reactions occurring more frequently in VOXZOGO-treated subjects than placebo.<\/small><br>\n<small><sup>&#x2021;<\/sup>Includes the preferred terms: gastroenteritis and gastroenteritis, viral.<\/small><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69fb5d002fec3\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-69fb5d003021f\" class=\"block single-video no-video-link\" data-muted-autoplay=\"false\">\n    <div class=\"wrapper\">\n\t\t<div class=\"video-poster\">\n\t\t\t\t\t<a class=\"no-video\" style=\"background-image: url(https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2026\/06\/amanda-blank-1.png?v=0.179);\"><\/a>\n\t\t\n\t\t\t\t\t<div class=\"video-note\">\n\t\t\t\t<p>Sophie, 9 months old, on VOXZOGO since 3 months old<\/p>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"video-details\">\n\t\t\t<div class=\"video-details-inner\">\n\t\t\t    \t\t\t\t                    <div class=\"supporting-text\">\n                        <h2 style=\"color: #ffffff;text-align: center\">&#x201C;We did our research, and knowing that VOXZOGO has been prescribed to over 5,000 children and is available from birth made us confident in our decision to treat Sophie with it.&#x201D;<\/h2>\n<p>&#x2013; Amanda, Sophie&#x2019;s mom<\/p>\n\t\t\t\t    <\/div>\n                \t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69fb5d003026a\" class=\"block wrapped-content block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-69fb5d0030298\" class=\"block-wysiwyg\">\n            <h3>Children under 5 years old<\/h3>\n<p>The safety of VOXZOGO in children under 5 years old was similar to that seen in children ages 5 years and older.<\/p>\n<p>Over 1 year, the most common side effects seen in over 10% of children on VOXZOGO (under 5 years old) were injection site reactions (86%) and rash (28%).<\/p>\n<h3 style=\"text-align: center\">In ongoing studies of VOXZOGO, the side effects observed for up to 4 years of treatment (see table below) are similar to those seen in the first year.<\/h3>\n    <\/div>\n\n<figure id=\"acf-block-69fb5d00302dc\">\n    <div class=\"image image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2026\/05\/under-5-1900x867.png\" alt=\"Table of VOXZOGO side effects at 4 years of treatment in 67 children, including total, serious, and common side effects\"\/>            <\/div>\n    <\/figure>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69fb5d0030330\" class=\"block call-to-action vox-cta lightpurple\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"box\">\n                <div class=\"vox-cta-content\">\n                                        \n                                        \n                                            <h2 style=\"text-align: center;color: #685bc7\">In children who started treatment at 4 months <strong>to under 2 years old,<\/strong><br>\n<strong>the side effects observed after 4 years of treatment were similar<\/strong><br>\nto those seen in children who started treatment at age 2 years or older.<\/h2>\n                                        \n                                    <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69fb5d0030368\" class=\"block wrapped-content block-zero-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-69fb5d003038d\" class=\"block-wysiwyg\">\n            <p><small>*Data combined from children under 2 years old and 2 to under 5 years old at the start of treatment in clinical trials.<\/small><br>\n<small><sup>&#x2020;<\/sup>None of the hypersensitivity side effects were severe, medically significant, or life threatening.<\/small><br>\n<small><sup>&#x2021;<\/sup>None of the injection site reaction side effects were moderate, severe, medically significant, or life threatening.<\/small><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69fb5d00303ce\" class=\"block call-to-action vox-cta magenta\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"box\">\n                <div class=\"vox-cta-content\">\n                                        \n                                            <h3>Giving VOXZOGO<\/h3>\n                                        \n                                            <p>Learn about administering treatment to your child.<\/p>\n                                        \n                                            <a href=\"https:\/\/www.voxzogo.com\/en-us\/giving-voxzogo\/\" class=\"button button-text button-graphic\" target=\"\">\n                            <img decoding=\"async\" class=\"icon\" src=\"https:\/\/www.voxzogo.com\/en-us\/wp-content\/uploads\/sites\/5\/2026\/05\/administer.svg\" alt=\"\"\/>                            See How                        <\/a>\n                                    <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69fb5d00306aa\" class=\"block wide-call-to-action\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cta-content\">\n                                    <div class=\"title-block\">\n                        <h2>Looking for more information about VOXZOGO?<\/h2>\n                    <\/div>\n                                <div class=\"content-block\">\n                                            <p>Your local BioMarin representative can help you find answers.<\/p>\n                                                                \n                        <p><a class=\"button button-ghost button-arrow\" href=\"https:\/\/www.voxzogo.com\/en-us\/connect-with-a-rep\/\" target=\"_self\">Connect Now<\/a><\/p>\n                                    <\/div>\n            <\/div>            \n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-6383","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>VOXZOGO\u00ae Safety: Side Effects and Long-term Safety Profile<\/title>\n<meta name=\"description\" content=\"Learn about VOXZOGO\u00ae safety, including side effects and important safety information, for children with achondroplasia.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.voxzogo.com\/en-us\/understanding-safety\/\" \/>\n<meta property=\"og:locale\" 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