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- How VOXZOGO Can Help
VOXZOGO improved growth rates in children with achondroplasia aged 5 years and up with open growth platesThe clinical trial focused on how VOXZOGO® (vosoritide) affects growth rate, or annualized growth velocity (AGV), a measure of bone growth over 1 year.* When the clinical trial began, it had a total of 121 participants:
*Data were collected at 1 year. An extension study is ongoing to evaluate the long-term efficacy and safety of VOXZOGO.
children received a daily injection of VOXZOGO
children received a daily injection without medication (placebo)
was maintained for children receiving VOXZOGO for
In achondroplasia, growth rates vary by age, sex, and individual, and generally decline through childhood. Individual growth rates with VOXZOGO may be different and may change over time.
In the VOXZOGO Prescribing Information, measurements are presented in centimeters. Measurements presented here have been converted to inches by dividing by 2.54 and rounding to the nearest hundredth.
Side effects can occur with VOXZOGO
In the clinical trial, 121 children received daily injections of either VOXZOGO® (vosoritide) or placebo. This chart shows the number of patients who experienced the most common side effects on VOXZOGO compared with placebo over 1 year.
*Includes adverse reactions occurring in over 10% of VOXZOGO patients and more frequently in the VOXZOGO arm with a risk difference of ≥5% (ie, difference of >2 subjects) between treatment arms.
†Injection site reactions occurring more frequently in VOXZOGO-treated subjects than placebo.
‡Includes the preferred terms: gastroenteritis and gastroenteritis, viral.
- VOXZOGO may cause serious side effects including a temporary decrease in blood pressure in some patients
- You can reduce the risk of decreased blood pressure and associated symptoms (dizziness, feeling tired, or nausea) by following these steps in the hour prior to receiving VOXZOGO:
(58/60) of children stayed on VOXZOGO treatment during the 1 year clinical trial
- One child discontinued due to pain from injections
- One child discontinued due to fear of needles