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Understanding bone growth and how VOXZOGO works
In achondroplasia, bone growth is impairedMost bones start to grow before birth and continue for as long as the bones' growth plates stay open. While the growth plates are open, there is an opportunity for growth.
Achondroplasia affects endochondral bone growth—this is bone growth that replaces cartilage with bone tissue as your child grows. Endochondral bone growth occurs in over 90% of bones in the body and takes place at the growth plate.
This image is for illustrative purposes only to show areas of endochondral bone growth.
Watch how VOXZOGO works in the body
A balance is important for bone growthA balance between fibroblast growth factor receptor 3 (FGFR3) and C-type natriuretic peptide (CNP) signaling pathways occurs within the cells in the growth plate. Bone development without achondroplasia FGFR3 slows bone growth while CNP promotes bone growth
This graphic illustrates the relationship between FGFR3 and CNP, and does not reflect the changing nature of the body’s signaling and bone growth processes.
Bone development with achondroplasia In achondroplasia, FGFR3 sends more signals to slow bone growth than it should. The body’s CNP is not enough to balance overactive FGFR3 signaling. Achondroplasia tilts the balance and slows down bone growth
This graphic illustrates the relationship between FGFR3 and CNP in achondroplasia but is not to scale and does not reflect a percentage of growth.
VOXZOGO is a molecule that stimulates the CNP pathwayVOXZOGO works alongside the body’s natural CNP to stimulate the CNP signaling pathway to promote bone growth. VOXZOGO bolsters CNP signaling to improve the balance with overactive FGFR3 signaling
This graphic shows how VOXZOGO works to increase CNP signaling but is not to scale and does not reflect a percentage of growth.